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Two Offprints on the Structure of Insulin; La Structure de l’Insuline [and] The Disulphide Bonds of Insulin by Sanger, Frederick

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$5,750.00

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Seller: Biblioctopus

Title: Two Offprints on the Structure of Insulin; La Structure de l’Insuline [and] The Disulphide Bonds of Insulin
Author: Sanger, Frederick
Seller: Biblioctopus (United States)
Description: 1955. First Edition. Sanger received the Nobel Prize in Chemistry in 1958 for determining the complete amino acid sequence of insulin (the first protein ever to have its primary structure fully established) and a second in 1980 for developing methods for sequencing DNA, making him one of only four individuals ever to have received two Nobel Prizes. The two offprints offered here, both signed by Sanger, together constitute the complete published record of that first achievement: a synthetic lecture delivered in Marseille in December 1954 presenting the full sequential strategy by which insulin’s structure was approached, and the definitive experimental paper establishing the positions of its three disulphide bridges—the final structural question the sequence work had left open. In demonstrating that a protein possesses a unique, fully definable covalent sequence, Sanger established the conceptual and methodological foundation upon which all subsequent structural biology rests. The principle that biological function is encoded in a specific primary sequence underlies every protein sequenced since, every therapeutic protein produced by recombinant technology, and every drug designed to interact with a defined molecular target; and the sequential degradation strategy Sanger developed for insulin was the direct intellectual precursor of the DNA sequencing methodology for which he received his second Nobel Prize; and which in turn made the Human Genome Project possible. (1) La Structure de l'Insuline; from Bulletin de la Société de Chimie biologique, Tome XXXVII, no. 1, pp.23–35. Paris: Masson et Cie, 1955. Offprint, 8vo (242 x 159mm), pp. 13, [3]. Original blue printed wrappers, staple-bound, some toning and rubbing, else near fine. Signed by Sanger on the front wrapper. A lecture delivered on 13 December 1954 in Marseille, in which Sanger presents a synthetic account of the decade-long experimental program at the Department of Biochemistry, University of Cambridge, that resulted in the complete elucidation of the amino acid sequence of insulin; the first protein ever to have its primary structure fully determined. Setting aside earlier disputed molecular weight values in favor of a minimum covalent unit of 6,000 (later calculated at 5,734), Sanger describes the sequential strategy by which the complete structure was approached: first, the identification of two N-terminal residues (DNP-glycine and DNP-phenylalanine, one equivalent of each) using the fluorodinitrobenzene reagent he had himself introduced in 1945, establishing that insulin comprises two distinct polypeptide chains; then the separation of those chains by performic acid oxidation, which cleaved the cystine disulfide bridges and resolved the molecule into a glycyl chain A of approximately 20 residues and a phenylalanyl chain B of approximately 30; then the stepwise determination of the N-terminal sequences of both chains by partial hydrolysis and partition chromatography, establishing that chain B begins Phe.Val.Asp.Glu and chain A begins Gly.Ileu.Val.Glu.Glu; and finally the mapping of the disulfide bridge positions, including an intrachain ring at positions A6 and A11 whose dimensions Sanger notes are shared by oxytocin and vasopressin, and the two interchain bridges connecting A and B, determined through systematic chymotryptic and peptic hydrolysis under conditions preventing disulfide exchange. The significance of the work extends far beyond insulin: in demonstrating that a protein possesses a unique, fully definable covalent sequence, Sanger established the conceptual and methodological foundation upon which all subsequent structural biology rests, and the principle that biological function is encoded in a specific primary sequence underlies every protein sequenced since, every therapeutic protein produced by recombinant technology, and every drug designed to interact with a defined molecular target. Sanger received the Nobel Prize in Chemistry in 1958 for this work, and a second in 1980 for DNA sequencing, making him one of only four individuals ever to have received two Nobel Prizes. (2) The Disulphide Bonds of Insulin; from The Biochemical Journal, Vol. 60, No. 4, pp. 541–556. London: Portland Press, 1955. Offprint, 8vo (254 x 185mm), pp. 16. String-bound self-wrappers, soft creases, a few scattered spots of soiling, near fine. Signed by Sanger on the front wrapper. Received 26 November 1954 at the Department of Biochemistry, University of Cambridge, this paper by Ryle, Sanger, Smith, and Kitai addresses the final structural question left open by the sequence determinations of the preceding years: the positions of the three disulphide bridges linking its six half-cystine residues. The paper begins by establishing the molecular weight of insulin as 5,734, calculated from the condensation of its constituent amino acids, and confirms that the molecule comprises two polypeptide chains (the glycyl chain A and the phenylalanyl chain B) joined by the disulphide bridges of three cystine residues, with fraction A containing four cysteic acid residues and fraction B two on oxidation. The experimental strategy proceeds in five defined stages: partial hydrolysis of insulin under conditions in which the disulphide bonds remained intact; fractionation of the resulting cystine-containing peptides; oxidation of those peptides to the corresponding cysteic acid peptides; fractionation of the cysteic acid peptides; and identification of their structures from the amino acids produced on hydrolysis. The central technical difficulty throughout was the prevention of disulphide interchange, which occurred readily under neutral conditions catalysed by thiol compounds and could be inhibited by N-ethylmaleimide (NEMI), and more slowly under acid conditions, particularly in H SO rather than HCl. The primary separation method was high-voltage paper ionophoresis in pyridine-acetic acid buffers, which the authors found more reliable than paper chromatography for resolving cystine-containing peptides, supplemented by ion-exchange chromatography on Amberlite IR-4B and two-dimensional ionophoresis. Hydrolysis was carried out with chymotrypsin, with a crude pancreatic extract, and with acid, each providing complementary peptide populations; no enzyme could be found capable of cleaving between the half-cystine residues at positions A6 and A7, so acid hydrolysis was required to locate the remaining two disulphide bridges. The results, summarized in Table 10, establish the complete disulphide connectivity of insulin: an intrachain ring connecting positions A6 and A11 of the glycyl chain — a ring of the same size as those found in oxytocin and vasopressin, a structural parallel the authors note may have possible structural or biological significance — and two interchain bridges connecting A20 to B19 and A7 to B7. This paper completes the structural determination of insulin begun in Sanger's earlier sequence work, and together they constitute the first complete covalent structure of any protein — a landmark from which the entire subsequent program of structural molecular biology and rational protein-based drug design descends.

Waiting for Godot by Beckett, Samuel

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$4,500.00

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Seller: Bookbid Rare Books

Title: Waiting for Godot
Author: Beckett, Samuel
Seller: Bookbid Rare Books (United States)
Condition: near fine
Description: Grove Press, 1970. signed limited. hardcover. near fine. Signed limited edition, 1/200 copies. This copy is not numbered. Near fine, sun tanning on spine. Housed in a custom-made slipcase.

The Poetical Works of John Greenleaf Whittier [with] Life and Letters of... (Artist's Edition in 9 vols.) by Whittier, John Greenleaf

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$1,500.00

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Seller: Whitmore Rare Books

Title: The Poetical Works of John Greenleaf Whittier [with] Life and Letters of... (Artist's Edition in 9 vols.)
Author: Whittier, John Greenleaf
Seller: Whitmore Rare Books (United States)
Condition: Fine
Description: Boston and New York: Houghton Mifflin and Company, The Riverside Press, 1894. First edition. Fine. Number 440 of 750 sets. Bound by the Riverside Press in full crushed olive morocco, spines uniformly faded. Nine volumes (6 x 8 1/2 inches) occupying approximately 16 1/2 inches (42 cm.) of shelf space. Top edges gilt. Raised bands and gilt floral patterns in the spine compartments and corners. Full inner red morocco doublures (with gilt decorations) red silk end papers. Bound with an autograph letter from Whittier tipped into the first volume. Each volume with two frontispieces, one in color. A lavish production overall. Illustrated throughout with plates, portraits and photogravures by Howard Pyle, Frank T. Merrill, Frederic Remington and F.O.A.C. Darley, among others. A Fine set. In the long struggle to abolish slavery, John Greenleaf Whittier became one of the most influential voices. "A highly regarded poet of the 19th century, he was enshrined in the pantheon of 'Schoolroom Poets' along with William Cullen Bryant, Ralph Waldo Emerson...and Oliver Wendell Holmes" (Poetry Foundation). His Quaker belief in tolerance and his friendship with activist William Lloyd Garrison combined to make both the poet and his poetry fiercely abolitionist. And indeed, in seeing the appeal of Whittier's poetry, Garrison enlisted his friend to publish on the cause's behalf and shift the tides in New England, where the abolitionist position was still unpopular. Here in a lovely binding, beautifully illustrated, are a selection of the works which made Whittier such an influential voice in his own time. Fine.

[AMERICAN "SHITPOST" 1852]. Life of Lord Timothy Dexter. [ISSUED WITH]: A Pickle for the Knowing Ones: or Plain Truths in a Homespun Dress by [Dexter, Timothy]. Knapp, Samuel L.

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$1,320.00

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Seller: Michael Laird Rare Books LLC

Title: [AMERICAN "SHITPOST" 1852]. Life of Lord Timothy Dexter. [ISSUED WITH]: A Pickle for the Knowing Ones: or Plain Truths in a Homespun Dress
Author: [Dexter, Timothy]. Knapp, Samuel L.
Seller: Michael Laird Rare Books LLC (United States)
Condition: Good
Description: Newburyport: John G. Tilton, 1852. Later edition. Good. Together two parts in one volume. 12mo. Ad 1: viii, [1], 10-107, with a woodcut frontispiece of Dexter's mansion, a half-page woodcut of Dexter on p. viii, and a full-page woodcut of Jonathan Plummer on p. [108] opposite the facing title page; Ad 2: 36 pp., title-page vignette of Dexter and his dog (verso blank. Original stab-stitched self wrappers (both stained and darkened). Original publisher's brown cloth, upper cover with gilt depiction of Timothy Dexter and his dog (spine defective but boards are quite sound as are the hinges; pastedowns and endpapers foxed but the textblock is remarkably clean and crisp). With faults and priced accordingly. "A PICKLE FOR THE KNOWING ONES" IS ONE OF THE EARLIEST AND MOST SPECTACULAR AMERICAN EXPRESSIONS OF VAIN IGNORANCE. SELF-STYLED "LORD" DEXTER, THIS UNEDUCATED MAN IS CONSIDERED THE LUCKIEST INVESTOR OF HIS DAY. MANY "UPPER CLASS" BUSINESSMEN DESPISED HIS GRANDIOSITY AND ENVIED HIS HYPERGAMIC WEALTH. ATTEMPTING TO RUIN HIM, THEY GLEEFULLY COAXED HIM INTO INVESTING IN NUMEROUS, SEEMINGLY "RIDICULOUS" VENTURES. ULTIMATELY, AND MOST IMPROBABLY, HE PROFITED WILDLY FROM THE VERY SCHEMES THEY PRIVATELY CONSIDERED ABSURD. THIS IS THE ONLY COPY OF ANY EARLY EDITION CURRENTLY ON THE MARKET. Dexter quit school at the age of eight. Eschewing editorial assistance, the words in his "Pickle for the Knowing Ones" are spelled phonetically. The first edition of 1802 was privately published and freely distributed by the author. Dexter was criticized to the point of ridicule. In response to complaints from readers about the absence of punctuation, in the second edition he instructed the printer to add multiple commas, periods, and exclamation points at the very end of the text (only) for readers to "peper and solt it as they plese." Online, this extraordinary text has been justifiably described as "The First American Shitpost." It contains equal parts of inflated autobiography, nonsense tirade, and "aristocratic" decree. Our author attacks almost everyone: politicians, ministers, and even his wife whom he married for her wealth at the age of 18 (she was 32-year-old widow). Incredibly, he grew immensely rich through blind investment decisions that should have been ruinous, for instance: spending his wife's fortune on Continental currency that had become nearly worthless; several years later its value (fortuitously) returned to parity; shipping coal to Newcastle (!) which fortuitously arrived during a miners' strike, and in doing so codified the phrase "selling coal to Newcastle"; sending 40,000 warming pans (!) to the West Indies where they sold out, having been fortuitously adapted for refining molasses; and to the same destination gloves (!), where they were bought en bloc by exporters to Siberia. The book's madness mirrors Dexter's life. Always desperate for attention, he staged his own funeral to see who would show up. Seeing that his wife's expressions of grief were (in his opinion) insufficient, he chased from the church and beat her with his cane. During their unfortunate marriage he called her a "ghost" despite the fact that she was still alive. His vanity was just as unrestrained: he declared himself the greatest philosopher of his age and imagining himself worthy of becoming Emperor of the United States. His estate became a monument to self-worship: alongside 40 giant wooden statues of heroes and statesmen, Dexter positioned his own statue, pronouncing himself as "The Greatest Philosopher in the Western World." Sound familiar? The present edition contains Samuel L. Knapp's highly entertaining biography of Dexter which is particularly valuable as it contains "Sketches Of The Eccentric Characters That Composed His Associates." These eccentrics are too numerous to name in full but include: Samuel Lord Dexter, Dexter's "imbecile" son; Nancy Bishop whose life deteriorates into "fatuity and wretchedness"; John P., the schoolmaster/astrologer, a "dare-devil" and "man of perpetual contradictions" who claimed powers in judicial astrology; Madam Hooper, a fortune-teller and "singularly bold, intelligent woman" who becomes one of Dexter's occult advisers; Moll Pitcher, the "celebrated" fortune-teller Dexter consults after Madam Hooper's death; Lucy Lancaster, the "female African" who had the greatest influence over Dexter's household and served as nurse/confidante/manager; T.B., the watchmaker who becomes a sounding board for Dexter's absurd metaphysics about time, God, ministers, and human nature; William Burley / "Dwarf Billy," a gigantic laborer hired by Dexter to do double work, eat double food, and serve as his fighter; the Dog-Town herb-women / "weird sisters," a collective of ragged women on skeletal horses, gathering herbs and distilling essences, and many more. Preceeding Dexter's "Pickle for the Knowing Ones" is an absurdly aggrandized "Life and Genius of Lord Dexter" written by Dexter's "poet laureate" Jonathan Plummer. MUST BE SEEN TO BE FULLY APPRECIATED.

Cours D'Architecture, qui comprend les Ordres De Vignole; Aves des Commentaires, les Figures & Descritions de fes plus beaux Batimens, & de Ceux de Michel-Ange (Course of Architecture, which includes the Orders of Vignola; With Commentaries, Figures & Descriptions of his most beautiful Architectural Works, & those of Michelangelo) by (Vignola, Giacomo Barozzi da). Daviler, A. C. (Augustine Charles d'Aviler)

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$950.00

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Seller: Eric Chaim Kline - Bookseller

Title: Cours D'Architecture, qui comprend les Ordres De Vignole; Aves des Commentaires, les Figures & Descritions de fes plus beaux Batimens, & de Ceux de Michel-Ange (Course of Architecture, which includes the Orders of Vignola; With Commentaries, Figures & Descriptions of his most beautiful Architectural Works, & those of Michelangelo)
Author: (Vignola, Giacomo Barozzi da). Daviler, A. C. (Augustine Charles d'Aviler)
Seller: Eric Chaim Kline - Bookseller (United States)
Condition: Good to very good condition
Description: La Haye: Pierre Grosse & Jean Neaulme, 1730. First edition. Hardcover. Good to very good condition. Large Octavo. [45] leaves, 1 folding plate depicting geometric principles; 355pp., 31 folding plates. Bound in mottled calf with elaborate decor and gilt lettering on spine; raised bands. Red edges. Frontispiece engraving. Title page printed in red and black with publisher's device. Historiated headpiece, decorative initial. Contains preface, essay on the life of Jacques Barozzo de Vignole, a table of the plates, table of contents, a preface by Vignole, illustrated parts on moldings and choice of profiles at front. Without dictionary volume. Plain new designs, ornaments, and principle rules concerning the distribution, decorations, materials and construction of buildings, masonry, carpentry, roofing, locksmithing, gardening and everything that pertains to the Art of Building. With a complete explanation of all terms in alphabetical order by A. C. Dam, Architect to the King. Profusely illustrated with copperplate engravings in text and thirty-one additional folding plates depicting architectural details and ornamentation with descriptive text. Fowler: "From the point of view of the practical architect this Course d'Architecture was the best work of its kind yet issued and soon superseded François Blondel's Course d'Architecture, and was unrivaled until the publication of J. F. Blondel's work of the same title in 1771-1777." Fowler: "Vignola, another of the great protagonists of the Italian Renaissance, was as influencial in France, as Palladio was in England. There were numerous editions of his work, (39 of which are in the Fowler Collection)." Vignola, along with Serlio, Palladio and Scamozzi, comprised the four distinguished architectural theorists of the sixteenth century. Beginning as a painter, Vignola took up drawing, then architectural delineation and perspective; using these skills he drew many of the antiquities of Rome. Those endeavors had considerable influence on his designs. Vignola composed two architectural treatises, one on perspective and another on the Five Orders. Among the many important commissions Vignola enjoyed, his selection to complete St. Peter's Basilica in Rome after the death of Michelangelo stands preëminent. Text in French. Front and back cover with few light scuffs along top edge of front and back cover. Inked names on top of inside cover and front free endpaper. Some staining along edges of inside back cover and endpaper. Some age-toning of some plates along edges. References: cf. Fowler 32 (first ed. 1691).

Photograph Signed of Yvette Guilbert by BOUGHTON, ALICE

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$935.00

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Seller: Schulson Autographs

Title: Photograph Signed of Yvette Guilbert
Author: BOUGHTON, ALICE
Seller: Schulson Autographs (United States)
Description: Boughton signed the gelatin silver print of the immensely popular French singer and actress Yvette Guilbert (1865-1944) along the bottom margin in white ink, "Photograph by Alice Boughton." The image is identified on verso on tape, "Madame Yvette Guilbert to appear [sic] the Shubert-murat Theatre Aft. Apr. 6th." Below the tape,is the likely stamp of a publicist or agency. Above the tape, pencil docketing shows. Condition: some margin chipping at the cornered and slight bend at the lower left corner and at the "g" in Boughton. Signs of aging on verso. Photograph measures almost 8 1/2 x 6 1/4. Boughton belonged to Alfred Stieglitz's Photo-Secession group of photographers whose goal was to approach photography as a form of art. He included two of her photographs in his inaugural show in 1902. She was also active in promoting images of the educated, active "modern" woman who functioned beyond her home.

F. Scott Fitzgerald's Preface to This Side of Paradise. Edited by John R. Hopkins. by [Windhover Press]. Fitzgerald, F. Scott.

4 to 14 days for delivery

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$200.00

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Seller: Michael R. Thompson, Booksellers, ABAA/ILAB

Title: F. Scott Fitzgerald's Preface to This Side of Paradise. Edited by John R. Hopkins.
Author: [Windhover Press]. Fitzgerald, F. Scott.
Seller: Michael R. Thompson, Booksellers, ABAA/ILAB (United States)
Description: Iowa City: The Windhover Press, and BruccoliClark, 1975 One of 150 copies. Brown linen with printed paper label on front cover. . Tall, narrow octavo. . Tipped in portrait of Fitzgerald from a drawing by John Thein. Printed on Rives Heavy mould-made paper. A fine copy.

Personal Memoir of Daniel Drayton, for four years and four months A prisoner (for charity's sake) in Washington Jail. Including a narrative of the voyage and capture of the schooner Pearl

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$175.00

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Seller: De Wolfe and Wood

Title: Personal Memoir of Daniel Drayton, for four years and four months A prisoner (for charity's sake) in Washington Jail. Including a narrative of the voyage and capture of the schooner Pearl
Seller: De Wolfe and Wood (United States)
Description: Boston: Bela Marsh, 1855. 122 pp. The book is good, with minor nicks and wear to the binding. Foxing to the preliminary pages and the corner of the front flyleaf is lacking. Drayton was imprisoned in Washington, D.C., for helping enslaved people escape the South.

Work Hard, Study...And Keep Out Of Politics!; Adventures And Lessons From An Unexpected Public Life by Baker, James A.

2 to 8 days for delivery

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$175.00

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Seller: The First Edition Rare Books, LLC

Title: Work Hard, Study...And Keep Out Of Politics!; Adventures And Lessons From An Unexpected Public Life
Author: Baker, James A.
Seller: The First Edition Rare Books, LLC (United States)
ISBN: 9780399153778
Condition: Fine
Description: New Haven: G.P. Putnam's Sons, 2006. First Edition, First Printing. Hardcover. Fine/near fine. Signed first edition, first printing of Work Hard, Study...And Keep Out Of Politics! by Secretary of State James A. Baker, III.. Octavo, xvii, 460pp. Maroon hardcover, title in gilt on spine, author's initials on front cover. First edition with full number line on copyright page. In publisher's near fine dust jacket, faint shelf wear, retail price on front flap. Signed by former Secretary of State James A. Baker on the title page in black ink. A fine copy. James A. Baker served as White House Chief of Staff and Treasury Secretary for President Reagan, then Secretary of State for President George H.W. Bush. He reluctantly returned to his post as Chief of Staff shortly before George Bush lost his bid for reelection in 1992.

Exhibition postcard: Stephen Antonakos: Four Incomplete Square Neons (17 September-14 October 1974) by (ANTONAKOS, Stephen)

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$125.00

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Seller: Jonathan A. Hill, Bookseller, Inc.

Title: Exhibition postcard: Stephen Antonakos: Four Incomplete Square Neons (17 September-14 October 1974)
Author: (ANTONAKOS, Stephen)
Seller: Jonathan A. Hill, Bookseller, Inc. (United States)
Description: Printed on both sides. Postcard, mailed. Houston: Cusack Gallery, 1974. Postcard invitation to the 1974 Antonakos exhibition at Barbara Cusack’s gallery. Near fine. Mailed to photographer Eve Sonneman.

The Outer Reaches, favorite science-fiction tales chosen by their authors by ANTHOLOGY Derleth, August, Poul Anderson, Isaac Asimov, Ray Bradbury, L. Sprague de Camp, David H. Keller, Henry Kuttner, Clifford D. Simak, Clark Ashton Smith, Theodore Sturgeon

5 to 14 days for delivery

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$95.20

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Seller: THE FINE BOOKS COMPANY

Title: The Outer Reaches, favorite science-fiction tales chosen by their authors
Author: ANTHOLOGY Derleth, August, Poul Anderson, Isaac Asimov, Ray Bradbury, L. Sprague de Camp, David H. Keller, Henry Kuttner, Clifford D. Simak, Clark Ashton Smith, Theodore Sturgeon
Seller: THE FINE BOOKS COMPANY (United States)
Description: The Outer Reaches, favorite science-fiction tales chosen by their authors, Pellegrini & Cudahy, 1951, first edition, near fine in like dust-wrapper. Contributions by August Derleth, Poul Anderson, Isaac Asimov, Ray Bradbury, L. Sprague de Camp, David H. Keller, Henry Kuttner, Clifford D. Simak, Clark Ashton Smith, Theodore Sturgeon, et.al. Inscribed to Forrest J. Ackerman.

Chikubushima: Deploying the Sacred Arts in Momoyama Japan by Watsky, Andrew M.

3 to 6 days for delivery

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$40.00

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Seller: McBlain Books

Title: Chikubushima: Deploying the Sacred Arts in Momoyama Japan
Author: Watsky, Andrew M.
Seller: McBlain Books (United States)
ISBN: 9780295983271
Condition: Near Fine
Description: Seattle and London: University of Washington Press, 2004. Hardcover. Near Fine/Near Fine. illustrations (some color), index, xiv, 350p. dj.

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